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Parathyroid hormone

Medical Information about Parathyroid hormone

Abstract: 

Parathyroid hormone (PTH) is a hormone your parathyroid glands release to control calcium levels in your blood. It also controls phosphorus and vitamin D levels. If your body has too much or too little parathyroid hormone, it can cause symptoms related to abnormal blood calcium levels.

Functions of Parathyroid Hormone:

• Bones: Parathyroid hormone stimulates the release of small amounts of calcium from your bones into your bloodstream.

• Kidneys: Parathyroid hormone enables the production of active vitamin D (calcitriol) in your kidneys. PTH also signals your kidneys to retain calcium in your body rather than flushing it out through your urine.

• Small intestine: Parathyroid hormone signals your small intestine to absorb more calcium from the food you eat.

Symptoms of high parathyroid hormone levels:

• Joint pain and bone pain.

• More frequent urination and thirst.

• Muscle aches, weakness, cramping and twitches

• Fatigue.

• Depression

• Decrease in appetite.

• Nausea and vomiting.

• Constipation.

• If you experience these symptoms of hypercalcemia.

• It is important to contact your healthcare provider.

Symptoms of low parathyroid hormone levels:

o Tingling in your lips, fingers or feet.

o Muscle cramps.

o Dry skin and brittle fingernails.

o Brain fog or confusion.

o Seizures.

o Irregular heart rhythm

When should check with Doctor?

Parathyroid hormone is an important hormone that’s in charge of managing your blood calcium levels. If experiencing symptoms of hypercalcemia or hypocalcemia, such as issues with your muscles and cognitive function, it’s important to contact your healthcare provider. They can run some simple tests to see if your parathyroid hormone levels are the culprit.

Descriptions:

Parathyroid hormone injection is used together with calcium and vitamin D to control hypocalcemia (low calcium levels) in patients with hyperparathyroidism. Hypoparathyroidism is a condition that is caused when the parathyroid gland in the neck doesn_t make enough parathyroid hormone (PTH). This medicine is only available through a restricted access program. Doctors who are enrolled in the restricted program can write a prescription for this medicine.

Before Using:

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

Allergies:

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric:

Appropriate studies have not been performed on the relationship of age to the effects of parathyroid hormone injection in the pediatric population. Safety and efficacy have not been established.

Geriatric:

Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of parathyroid hormone injection in the elderly. However, elderly patients are more likely to have kidney problems, which may require caution and an adjustment in the dose for patients receiving this medicine.

Breastfeeding:

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Drug Interactions:

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

• Alendronate

Other Interactions:

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Other Medical Problems:

The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:

• Bone disease (eg, osteosarcoma, Paget_s disease of bone)—Use with caution. May make this condition worse.

• Kidney disease—Use with caution. The effects may be increased because of slower removal of the medicine to the body.

Proper Use:

A doctor or other trained health professional will give you this medicine. This medicine is given as a shot under your skin, usually on the upper thighs.

You may be taught how to give this medicine at home. Make sure you understand all of the instructions before giving yourself an injection. Do not use more medicine or use it more often than your doctor tells you to.

This medicine comes with a Medication Guide and patient instructions. Read and follow the instructions carefully. Ask your doctor if you have any questions about:

• How to prepare the injection using the medication cartridge and mixing device.

• The proper use of disposable syringes.

• How to give the injection using the reusable Q-Cliq pen injector.

• How long the injection can be stored at home.

If you have any questions about any of this, check with your doctor.

The medicine should be clear. Do not use the medicine if it is cloudy, discolored, or has large particles in it.

Follow your doctor_s instructions about how to take vitamin D and calcium supplements while using this medicine.

Dosing:

The dose of this medicine will be different for different patients. Follow your doctor_s orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

• For injection dosage form:

o For low calcium levels:

Adults—Dose must be determined by your doctor. The starting dose is usually 50 microgram (mcg) injected under the skin once a day. Your doctor may adjust your dose every 4 weeks as needed. However, the dose is usually not more than 100 mcg per day.

Children—Use and dose must be determined by your doctor.

Missed Dose:

If you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

Storage:

  Keep out of the reach of children.

  Do not keep outdated medicine or medicine no longer needed.

  Ask your healthcare professional how you should dispose of any medicine

 you do not use.

  Store in the refrigerator.

  Do not freeze.

Store away from heat and light. Do not freeze or shake. Throw away any unused mixed medicine in the medication cartridge.

Throw away used needles in a hard, closed container that the needles cannot poke through. Keep this container away from children and pets.

Precautions:

It is important that your doctor check your progress at regular visits to make sure this medicine is working properly. Blood and urine tests may be needed to check for unwanted effects.

This medicine may increase your risk of having osteosarcoma (bone tumor). This is more likely to occur if you have Paget_s disease of the bone, high levels of alkaline phosphatase, genetic disorders, children with open epiphyses, or a history of external beam or implant radiation therapy. Tell your doctor right away if you have bone pain that does not go away or a new soft tissue mass that is tender to palpitation.

Severe hypercalcemia (high calcium in the blood) may occur while using this medicine. This is more likely to occur when you start treatment or increase your dose. Call your doctor right away if you have confusion, constipation, dry mouth, metallic taste, muscle weakness, nausea or vomiting, or weight loss.

Do not stop using this medicine suddenly without asking your doctor. This may increase your risk of having severe hypocalcemia (low calcium in the blood). Symptoms include abdominal or stomach cramps, muscle spasms or twitching, numbness or tingling in your fingers, toes, or around your mouth, or trouble breathing.

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